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PAWR

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GENERAL INFORMATION

Gene name

 PAWR

Gene description

 PRKC, apoptosis, WT1, regulator

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & actin filaments.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated), Actin filaments (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA012640 , CAB020779
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & actin filaments.

Main location

 Plasma membrane (validated), Actin filaments (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA012640 A-431 Plasma membrane
Actin filaments
HPA012640 SiHa Plasma membrane
Actin filaments
HPA012640 U-2 OS No staining    
CAB020779 A-431 Plasma membrane
Actin filaments
CAB020779 U-2 OS No staining    
CAB020779 U-251 MG No staining    

GENE INFORMATION

Gene name

 PAWR (HGNC Symbol)

Synonyms

 par-4, PAR4

Description

 PRKC, apoptosis, WT1, regulator (HGNC Symbol)

Entrez gene summary

 The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q21.2

Chromosome location (bp)

 79574979 - 79691097

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177425 (version 83.38)

Entrez gene

 5074

UniProt

 Q96IZ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96IZ0

Antibodypedia

 PAWR antibodies

PROTEIN BROWSER
PAWR-001
PAWR-002
PAWR-006
PAWR-008
PAWR-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAWR-001
ENSP00000328088
ENST00000328827
Q96IZ0 [Direct mapping]
PRKC apoptosis WT1 regulator protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008157 [protein phosphatase 1 binding]
GO:0009611 [response to wounding]
GO:0010040 [response to iron(II) ion]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0030424 [axon]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042986 [positive regulation of amyloid precursor protein biosynthetic process]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045760 [positive regulation of action potential]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051017 [actin filament bundle assembly]
GO:0060450 [positive regulation of hindgut contraction]
GO:0071306 [cellular response to vitamin E]
GO:0071347 [cellular response to interleukin-1]
GO:0071372 [cellular response to follicle-stimulating hormone stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0090281 [negative regulation of calcium ion import]
GO:0097190 [apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:1901082 [positive regulation of relaxation of smooth muscle]
GO:1903238 [positive regulation of leukocyte tethering or rolling]
GO:1904457 [positive regulation of neuronal action potential]
GO:1990035 [calcium ion import into cell]
GO:2000391 [positive regulation of neutrophil extravasation]
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 340 aa
36.6 kDa 		No 0
PAWR-002
ENSP00000447454
ENST00000548426
F8W1M8 [Direct mapping]
PRKC apoptosis WT1 regulator protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006915 [apoptotic process]
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 76 aa
7.4 kDa 		No 0
PAWR-006
ENSP00000448317
ENST00000551712
H0YI16 [Direct mapping]
PRKC apoptosis WT1 regulator protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
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 194 aa
20.1 kDa 		No 0
PAWR-008
ENSP00000449928
ENST00000552637
A0A0B4J260 [Direct mapping]
PRKC apoptosis WT1 regulator protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
6.3 kDa 		No 0
PAWR-009
ENSP00000447507
ENST00000550603
H0YHP5 [Direct mapping]
PRKC apoptosis WT1 regulator protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
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 72 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.