Expression of ST8SIA3 in cancer - Summary

CANCER ATLAS

Gene description

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA063398

GENE INFORMATION
Gene name	ST8SIA3 (HGNC Symbol)
Synonyms	SIAT8C
Description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (HGNC Symbol)
Entrez gene summary	ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
Chromosome	18
Cytoband	q21.31
Chromosome location (bp)	57350813 - 57371731
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177511 (version 83.38)
Entrez gene	51046
UniProt	O43173 (UniProt - Evidence at protein level)
neXtProt	NX_O43173
Antibodypedia	ST8SIA3 antibodies

PROTEIN BROWSER

ST8SIA3-001	ST8SIA3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST8SIA3-001 ENSP00000320431 ENST00000324000	O43173 [Direct mapping] Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0001574 [ganglioside biosynthetic process] GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006491 [N-glycan processing] GO:0006688 [glycosphingolipid biosynthetic process] GO:0008373 [sialyltransferase activity] GO:0009100 [glycoprotein metabolic process] GO:0009311 [oligosaccharide metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0033691 [sialic acid binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	380 aa 44 kDa	No	1
ST8SIA3-003 ENSP00000467752 ENST00000586360	K7EQB3 [Direct mapping] Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase Show all	Predicted intracellular proteins Show all	GO:0005794 [Golgi apparatus] GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0016021 [integral component of membrane] GO:0097503 [sialylation] Show all	125 aa 14.6 kDa	No	0