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ST8SIA3

GENERAL INFORMATION

Gene name

 ST8SIA3

Gene description

 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, pituitary gland, hypothalamus, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in neurons with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA063398
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, pituitary gland, hypothalamus, hippocampus)

GENE INFORMATION

Gene name

 ST8SIA3 (HGNC Symbol)

Synonyms

 SIAT8C

Description

 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (HGNC Symbol)

Entrez gene summary

 ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]

Chromosome

 18

Cytoband

 q21.31

Chromosome location (bp)

 57350813 - 57371731

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177511 (version 83.38)

Entrez gene

 51046

UniProt

 O43173 (UniProt - Evidence at protein level)

neXtProt

 NX_O43173

Antibodypedia

 ST8SIA3 antibodies

PROTEIN BROWSER
ST8SIA3-001
ST8SIA3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ST8SIA3-001
ENSP00000320431
ENST00000324000
O43173 [Direct mapping]
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006491 [N-glycan processing]
GO:0006688 [glycosphingolipid biosynthetic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030173 [integral component of Golgi membrane]
GO:0033691 [sialic acid binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
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 380 aa
44 kDa 		No 1
ST8SIA3-003
ENSP00000467752
ENST00000586360
K7EQB3 [Direct mapping]
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
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Predicted intracellular proteins
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GO:0005794 [Golgi apparatus]
GO:0006486 [protein glycosylation]
GO:0008373 [sialyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0097503 [sialylation]
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 125 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.