Tissue expression of WDR6 - Summary - The Human Protein Atlas

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WDR6

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	WDR6
Gene description	WD repeat domain 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042622
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	WDR6
Synonyms
Description	WD repeat domain 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. [provided by RefSeq, Aug 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49007062 - 49015953
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178252 (version 83.38)
Entrez gene	11180
UniProt	Q9NNW5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NNW5
Antibodypedia	WDR6 antibodies

PROTEIN BROWSER

WDR6-001	WDR6-005	WDR6-008	WDR6-009	WDR6-010	WDR6-020	WDR6-022	WDR6-023	WDR6-024	WDR6-201	WDR6-202	WDR6-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR6-001 ENSP00000378857 ENST00000395474	A0A087X295 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0043234 [protein complex] GO:0043560 [insulin receptor substrate binding] Show all	1151 aa 125 kDa	No	0
WDR6-005 ENSP00000412195 ENST00000415265	E9PBK6 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	569 aa 62.2 kDa	No	0
WDR6-008 ENSP00000413432 ENST00000448293	E9PDU5 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	1070 aa 116.2 kDa	No	0
WDR6-009 ENSP00000390740 ENST00000419837	C9JFP6 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.5 kDa	No	0
WDR6-010 ENSP00000477418 ENST00000429900	V9GZ48 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.5 kDa	No	0
WDR6-020 ENSP00000387692 ENST00000438660	C9K020 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	271 aa 30.3 kDa	No	0
WDR6-022 ENSP00000477087 ENST00000489427	V9GYU1 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.2 kDa	No	0
WDR6-023 ENSP00000477463 ENST00000491365	V9GZ65 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 4 kDa	No	0
WDR6-024 ENSP00000477389 ENST00000608424	Q9NNW5 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007050 [cell cycle arrest] GO:0008180 [COP9 signalosome] GO:0008285 [negative regulation of cell proliferation] GO:0010507 [negative regulation of autophagy] GO:0044822 [poly(A) RNA binding] Show all	1121 aa 121.7 kDa	No	0
WDR6-201 ENSP00000484799 ENST00000610967	A0A087X295 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1151 aa 125 kDa	No	0
WDR6-202 ENSP00000482289 ENST00000615452	Q6PKC6 [Direct mapping] WD repeat-containing protein 6; WDR6 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	289 aa 32.1 kDa	No	0
WDR6-203 ENSP00000487056 ENST00000627177	F8WE36 [Direct mapping] WD repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.