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Most tumour tissues showed cases of moderate to strong granular cytoplasmic positivity. Prostate, cervical, pancreatic and gastric cancer were weakly stained or negative.
Majority of testicular cancers along with few cases of gliomas, ovarian, liver, colorectal, urothelial, lung and pancreatic cancers displayed moderate to strong cytoplasmic positivity. Other cancer tissues were in general weakly stained or negative.
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
