Cell atlas - GLDC - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GLDC
Gene description	Glycine dehydrogenase (decarboxylating)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (BEWO, RPTEC TERT1, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleus (uncertain)
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA052887
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, RPTEC TERT1, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleus.

Main location

Mitochondria (supported)

Additional location

Nucleus (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA052887	CACO-2	Nucleus
HPA052887	CACO-2	Mitochondria
HPA052887	Hep G2	Nucleus
HPA052887	Hep G2	Mitochondria
HPA052887	U-2 OS	Nucleoplasm
		Plasma membrane
		Mitochondria

MOUSE CELLS

Main location

Mitochondria

Additional location

Nucleoplasm, Cytosol

Mouse gene

ENSMUSG00000024827 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

GENE INFORMATION
Gene name	GLDC (HGNC Symbol)
Synonyms	GCSP, NKH
Description	Glycine dehydrogenase (decarboxylating) (HGNC Symbol)
Entrez gene summary	Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Chromosome	9
Cytoband	p24.1
Chromosome location (bp)	6532464 - 6645650
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178445 (version 83.38)
Entrez gene	2731
UniProt	P23378 (UniProt - Evidence at protein level)
neXtProt	NX_P23378
Antibodypedia	GLDC antibodies

PROTEIN BROWSER

GLDC-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLDC-001 ENSP00000370737 ENST00000321612	P23378 [Direct mapping] Glycine dehydrogenase (decarboxylating), mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004375 [glycine dehydrogenase (decarboxylating) activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005960 [glycine cleavage complex] GO:0006520 [cellular amino acid metabolic process] GO:0006544 [glycine metabolic process] GO:0006546 [glycine catabolic process] GO:0009055 [electron carrier activity] GO:0016594 [glycine binding] GO:0016829 [lyase activity] GO:0019464 [glycine decarboxylation via glycine cleavage system] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] GO:0055114 [oxidation-reduction process] Show all	1020 aa 112.7 kDa	No	0