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Several cases of hepatocellular carcinomas and prostate cancers along with a few cases of malignant gliomas, lung adenocarcinomas, colorectal, breast and ovarian cancers showed moderate cytoplasmic staining. Remaining cancer tissues were weakly stained or negative.
Few cases of testicular, prostate and breast cancers showed weak cytoplasmic immunoreactivity. Remaining cancer tissues were mostly negative.
GENE INFORMATION
Gene name
COX14 (HGNC Symbol)
Synonyms
C12orf62, MGC14288
Description
COX14 cytochrome c oxidase assembly factor (HGNC Symbol)
Entrez gene summary
This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
