Cell atlas - COX14 - The Human Protein Atlas

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COX14

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	COX14
Gene description	COX14 cytochrome c oxidase assembly factor
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA044618
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044618	A-431	Mitochondria
	HPA044618	U-2 OS	Mitochondria
	HPA044618	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	COX14 (HGNC Symbol)
Synonyms	C12orf62, MGC14288
Description	COX14 cytochrome c oxidase assembly factor (HGNC Symbol)
Entrez gene summary	This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	50111979 - 50120457
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178449 (version 83.38)
Entrez gene	84987
UniProt	Q96I36 (UniProt - Evidence at protein level)
neXtProt	NX_Q96I36
Antibodypedia	COX14 antibodies

PROTEIN BROWSER

COX14-001	COX14-002	COX14-003	COX14-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX14-001 ENSP00000446524 ENST00000550487	Q96I36 [Direct mapping] Cytochrome c oxidase assembly protein COX14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	57 aa 6.6 kDa	No	1
COX14-002 ENSP00000326052 ENST00000317943	Q96I36 [Direct mapping] Cytochrome c oxidase assembly protein COX14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	57 aa 6.6 kDa	No	1
COX14-003 ENSP00000447776 ENST00000548985	Q96I36 [Direct mapping] Cytochrome c oxidase assembly protein COX14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	57 aa 6.6 kDa	No	1
COX14-004 ENSP00000450331 ENST00000550654	Q96I36 [Direct mapping] Cytochrome c oxidase assembly protein COX14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	57 aa 6.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.