Cell atlas - SLC25A20 - The Human Protein Atlas

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SLC25A20

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	SLC25A20
Gene description	Solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & mitochondria.
RNA cell category	Cell line enhanced (RPMI-8226)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029863
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & mitochondria.

Main location

Mitochondria (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029863	PC-3	Mitochondria
	HPA029863	PC-3	Cytosol
	HPA029863	U-2 OS	Cytosol
	HPA029863	U-251 MG	Mitochondria
	HPA029863	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SLC25A20 (HGNC Symbol)
Synonyms	CAC, CACT
Description	Solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 (HGNC Symbol)
Entrez gene summary	This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48856931 - 48898993
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178537 (version 83.38)
Entrez gene	788
UniProt	O43772 (UniProt - Evidence at protein level)
neXtProt	NX_O43772
Antibodypedia	SLC25A20 antibodies

PROTEIN BROWSER

SLC25A20-001	SLC25A20-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A20-001 ENSP00000326305 ENST00000319017	O43772 [Direct mapping] Mitochondrial carnitine/acylcarnitine carrier protein Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006853 [carnitine shuttle] GO:0016021 [integral component of membrane] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	301 aa 32.9 kDa	No	5
SLC25A20-002 ENSP00000388986 ENST00000430379	C9JPE1 [Direct mapping] Mitochondrial carnitine/acylcarnitine carrier protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	228 aa 25.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.