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Most malignant cells displayed weak to moderate nuclear immunoreactivity. Several cases of malignant lymphomas and gliomas as well as ovarian cancers were negative.
GENE INFORMATION
Gene name
ERBB4 (HGNC Symbol)
Synonyms
ALS19, HER4
Description
Erb-b2 receptor tyrosine kinase 4 (HGNC Symbol)
Entrez gene summary
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]