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CTNNBIP1

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GENERAL INFORMATION

Gene name

 CTNNBIP1

Gene description

 Catenin, beta interacting protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, mitochondria & cell junctions.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cell Junctions (approved), Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA042617
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, mitochondria & cell junctions.

Main location

 Plasma membrane (approved), Cell Junctions (approved), Mitochondria (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042617 A-431 Cell Junctions
HPA042617 Hep G2 Mitochondria
HPA042617 U-2 OS Plasma membrane
Mitochondria

GENE INFORMATION

Gene name

 CTNNBIP1 (HGNC Symbol)

Synonyms

 ICAT, MGC15093

Description

 Catenin, beta interacting protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 9848276 - 9910336

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178585 (version 83.38)

Entrez gene

 56998

UniProt

 Q9NSA3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSA3

Antibodypedia

 CTNNBIP1 antibodies

PROTEIN BROWSER
CTNNBIP1-001
CTNNBIP1-002
CTNNBIP1-003
CTNNBIP1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTNNBIP1-001
ENSP00000366474
ENST00000377263
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0031333 [negative regulation of protein complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0060633 [negative regulation of transcription initiation from RNA polymerase II promoter]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0
CTNNBIP1-002
ENSP00000383696
ENST00000400904
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0032091 [negative regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0
CTNNBIP1-003
ENSP00000366468
ENST00000377258
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0032091 [negative regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0
CTNNBIP1-004
ENSP00000366466
ENST00000377256
Q9NSA3 [Direct mapping]
Beta-catenin-interacting protein 1
A0A024R4D7 [Target identity:100%; Query identity:100%]
Catenin, beta interacting protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008013 [beta-catenin binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0032091 [negative regulation of protein binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0070016 [armadillo repeat domain binding]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
Show all
 81 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.