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PSAPL1

CANCER ATLAS

Gene description

 Prosaposin-like 1 (gene/pseudogene)

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038013
HPA038482

GENE INFORMATION

Gene name

 PSAPL1

Synonyms

Description

 Prosaposin-like 1 (gene/pseudogene) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is related to the glycoprotein prosaposin. Based on sequence similarity between the encoded protein and prosaposin, it is predicted that the encoded protein is a preproprotein that is proteolytically processed to generate multiple protein products. These predicted products include saposins A-like, B-like, C-like, and D-like, which may play a role in the lysosomal degradation of sphingolipids. [provided by RefSeq, Jul 2015]

Chromosome

 4

Cytoband

 p16.1

Chromosome location (bp)

 7432258 - 7434945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178597 (version 83.38)

Entrez gene

 768239

UniProt

 Q6NUJ1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6NUJ1

Antibodypedia

 PSAPL1 antibodies

PROTEIN BROWSER
PSAPL1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSAPL1-001
ENSP00000317445
ENST00000319098
Q6NUJ1 [Direct mapping]
Proactivator polypeptide-like 1 Saposin A-like Saposin B-Val-like Saposin B-like Saposin C-like Saposin D-like
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0006629 [lipid metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0008047 [enzyme activator activity]
GO:0019216 [regulation of lipid metabolic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0060736 [prostate gland growth]
GO:0060742 [epithelial cell differentiation involved in prostate gland development]
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 521 aa
56.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.