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Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]
P20674 [Direct mapping] Cytochrome c oxidase subunit 5A, mitochondrial
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Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004129 [cytochrome-c oxidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005751 [mitochondrial respiratory chain complex IV] GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0009055 [electron carrier activity] GO:0010467 [gene expression] GO:0022904 [respiratory electron transport chain] GO:0043209 [myelin sheath] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:1902600 [hydrogen ion transmembrane transport]
