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FOXE1

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GENERAL INFORMATION

Gene name

 FOXE1

Gene description

 Forkhead box E1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SiHa, RPTEC TERT1, HeLa, A-431)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa, RPTEC TERT1, HeLa, A-431)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FOXE1 (HGNC Symbol)

Synonyms

 FKHL15, FOXE2, HFKH4, TITF2, TTF-2

Description

 Forkhead box E1 (HGNC Symbol)

Entrez gene summary

 This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.33

Chromosome location (bp)

 97853254 - 97856715

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178919 (version 83.38)

Entrez gene

 2304

UniProt

 O00358 (UniProt - Evidence at protein level)

neXtProt

 NX_O00358

Antibodypedia

 FOXE1 antibodies

PROTEIN BROWSER
FOXE1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXE1-001
ENSP00000364265
ENST00000375123
O00358 [Direct mapping]
Forkhead box protein E1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006590 [thyroid hormone generation]
GO:0009653 [anatomical structure morphogenesis]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030878 [thyroid gland development]
GO:0031069 [hair follicle morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048538 [thymus development]
GO:0048562 [embryonic organ morphogenesis]
GO:0060022 [hard palate development]
GO:0060023 [soft palate development]
GO:0060465 [pharynx development]
Show all
 373 aa
38.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.