Tissue expression of FOXE1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FOXE1
Gene description	Forkhead box E1
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (thyroid gland)
GTEx:	Tissue enriched (thyroid gland)
FANTOM5:	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (thyroid gland)

GENE INFORMATION
Gene name	FOXE1 (HGNC Symbol)
Synonyms	FKHL15, FOXE2, HFKH4, TITF2, TTF-2
Description	Forkhead box E1 (HGNC Symbol)
Entrez gene summary	This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q22.33
Chromosome location (bp)	97853254 - 97856715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178919 (version 83.38)
Entrez gene	2304
UniProt	O00358 (UniProt - Evidence at protein level)
neXtProt	NX_O00358
Antibodypedia	FOXE1 antibodies

PROTEIN BROWSER

FOXE1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXE1-001 ENSP00000364265 ENST00000375123	O00358 [Direct mapping] Forkhead box protein E1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006590 [thyroid hormone generation] GO:0009653 [anatomical structure morphogenesis] GO:0016477 [cell migration] GO:0030154 [cell differentiation] GO:0030878 [thyroid gland development] GO:0031069 [hair follicle morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048538 [thymus development] GO:0048562 [embryonic organ morphogenesis] GO:0060022 [hard palate development] GO:0060023 [soft palate development] GO:0060465 [pharynx development] Show all	373 aa 38.1 kDa	No	0