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SNX18

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GENERAL INFORMATION

Gene name

 SNX18

Gene description

 Sorting nexin 18

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA037800
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA037800 A-431 Cytosol
HPA037800 U-2 OS Cytosol
HPA037800 U-251 MG Cytosol

GENE INFORMATION

Gene name

 SNX18 (HGNC Symbol)

Synonyms

 SH3PX2, SH3PXD3B, SNAG1

Description

 Sorting nexin 18 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 54517759 - 54546585

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178996 (version 83.38)

Entrez gene

 112574

UniProt

 Q96RF0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RF0

Antibodypedia

 SNX18 antibodies

PROTEIN BROWSER
SNX18-001
SNX18-002
SNX18-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX18-001
ENSP00000317332
ENST00000326277
Q96RF0 [Direct mapping]
Sorting nexin-18
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007067 [mitotic nuclear division]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0016197 [endosomal transport]
GO:0030136 [clathrin-coated vesicle]
GO:0030426 [growth cone]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0036089 [cleavage furrow formation]
GO:0043025 [neuronal cell body]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
Show all
 628 aa
68.9 kDa 		No 0
SNX18-002
ENSP00000370817
ENST00000381410
Q96RF0 [Direct mapping]
Sorting nexin-18
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007067 [mitotic nuclear division]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0016197 [endosomal transport]
GO:0030136 [clathrin-coated vesicle]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0036089 [cleavage furrow formation]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
Show all
 624 aa
69 kDa 		No 0
SNX18-201
ENSP00000342276
ENST00000343017
Q96RF0 [Direct mapping]
Sorting nexin-18
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007067 [mitotic nuclear division]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0016197 [endosomal transport]
GO:0030136 [clathrin-coated vesicle]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0036089 [cleavage furrow formation]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
Show all
 591 aa
64.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.