Expression of CYC1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cytochrome c-1

Protein class

Disease related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001247

GENE INFORMATION
Gene name	CYC1 (HGNC Symbol)
Synonyms	UQCR4
Description	Cytochrome c-1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144095027 - 144097525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179091 (version 83.38)
Entrez gene	1537
UniProt	P08574 (UniProt - Evidence at protein level)
neXtProt	NX_P08574
Antibodypedia	CYC1 antibodies

PROTEIN BROWSER

CYC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYC1-001 ENSP00000317159 ENST00000318911	P08574 [Direct mapping] Cytochrome c1, heme protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0033762 [response to glucagon] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045155 [electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity] GO:0046872 [metal ion binding] GO:0070469 [respiratory chain] Show all	325 aa 35.4 kDa	No	2