Cell atlas - CYC1 - The Human Protein Atlas

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CYC1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	CYC1
Gene description	Cytochrome c-1
Protein class	Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA001247
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001247	U-2 OS	Mitochondria
	HPA001247	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	CYC1 (HGNC Symbol)
Synonyms	UQCR4
Description	Cytochrome c-1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	144095027 - 144097525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179091 (version 83.38)
Entrez gene	1537
UniProt	P08574 (UniProt - Evidence at protein level)
neXtProt	NX_P08574
Antibodypedia	CYC1 antibodies

PROTEIN BROWSER

CYC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYC1-001 ENSP00000317159 ENST00000318911	P08574 [Direct mapping] Cytochrome c1, heme protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0033762 [response to glucagon] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045155 [electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity] GO:0046872 [metal ion binding] GO:0070469 [respiratory chain] Show all	325 aa 35.4 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.