Expression of MKRN3 in cancer - Summary

CANCER ATLAS

Gene description

Makorin ring finger protein 3

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029494

GENE INFORMATION
Gene name	MKRN3 (HGNC Symbol)
Synonyms	D15S9, MGC88288, RNF63, ZFP127, ZNF127
Description	Makorin ring finger protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q11.2
Chromosome location (bp)	23565678 - 23630075
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179455 (version 83.38)
Entrez gene	7681
UniProt	Q13064 (UniProt - Evidence at protein level)
neXtProt	NX_Q13064
Antibodypedia	MKRN3 antibodies

PROTEIN BROWSER

MKRN3-001	MKRN3-003	MKRN3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKRN3-001 ENSP00000313881 ENST00000314520	Q13064 [Direct mapping] Probable E3 ubiquitin-protein ligase makorin-3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030529 [ribonucleoprotein complex] GO:0046872 [metal ion binding] Show all	507 aa 55.6 kDa	No	0
MKRN3-003 ENSP00000455368 ENST00000564592	H3BPL3 [Direct mapping] Probable E3 ubiquitin-protein ligase makorin-3 Show all	Predicted intracellular proteins Show all		182 aa 19.6 kDa	No	0
MKRN3-005 ENSP00000456779 ENST00000568252	Q6NSB6 [Direct mapping] MKRN3 protein; Probable E3 ubiquitin-protein ligase makorin-3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	105 aa 10.5 kDa	No	0