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MKRN3

GENERAL INFORMATION

Gene name

 MKRN3

Gene description

 Makorin ring finger protein 3

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, placenta, testis)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA029494
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, placenta, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 MKRN3 (HGNC Symbol)

Synonyms

 D15S9, MGC88288, RNF63, ZFP127, ZNF127

Description

 Makorin ring finger protein 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q11.2

Chromosome location (bp)

 23565678 - 23630075

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179455 (version 83.38)

Entrez gene

 7681

UniProt

 Q13064 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13064

Antibodypedia

 MKRN3 antibodies

PROTEIN BROWSER
MKRN3-001
MKRN3-003
MKRN3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKRN3-001
ENSP00000313881
ENST00000314520
Q13064 [Direct mapping]
Probable E3 ubiquitin-protein ligase makorin-3
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030529 [ribonucleoprotein complex]
GO:0046872 [metal ion binding]
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 507 aa
55.6 kDa 		No 0
MKRN3-003
ENSP00000455368
ENST00000564592
H3BPL3 [Direct mapping]
Probable E3 ubiquitin-protein ligase makorin-3
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Predicted intracellular proteins
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 182 aa
19.6 kDa 		No 0
MKRN3-005
ENSP00000456779
ENST00000568252
Q6NSB6 [Direct mapping]
MKRN3 protein; Probable E3 ubiquitin-protein ligase makorin-3
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Predicted intracellular proteins
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GO:0005515 [protein binding]
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 105 aa
10.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.