Expression of CIITA in cancer - Summary

CANCER ATLAS

Gene description

Class II, major histocompatibility complex, transactivator

Protein class

Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

CAB016084

GENE INFORMATION
Gene name	CIITA (HGNC Symbol)
Synonyms	C2TA, MHC2TA, NLRA
Description	Class II, major histocompatibility complex, transactivator (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the ""master control factor"" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	16
Cytoband	p13.13
Chromosome location (bp)	10877198 - 10932281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179583 (version 83.38)
Entrez gene	4261
UniProt	P33076 (UniProt - Evidence at protein level)
neXtProt	NX_P33076
Antibodypedia	CIITA antibodies

PROTEIN BROWSER

CIITA-001	CIITA-002	CIITA-008	CIITA-201	CIITA-202	CIITA-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CIITA-001 ENSP00000316328 ENST00000324288	A0A0B4J1S1 [Direct mapping] MHC class II transactivator Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	1130 aa 123.4 kDa	No	0
CIITA-002 ENSP00000371257 ENST00000381835	P33076 [Direct mapping] MHC class II transactivator Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006955 [immune response] GO:0008022 [protein C-terminus binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016605 [PML body] GO:0016746 [transferase activity, transferring acyl groups] GO:0019221 [cytokine-mediated signaling pathway] GO:0032403 [protein complex binding] GO:0032966 [negative regulation of collagen biosynthetic process] GO:0033613 [activating transcription factor binding] GO:0034341 [response to interferon-gamma] GO:0044212 [transcription regulatory region DNA binding] GO:0045345 [positive regulation of MHC class I biosynthetic process] GO:0045348 [positive regulation of MHC class II biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046677 [response to antibiotic] GO:0060333 [interferon-gamma-mediated signaling pathway] Show all	546 aa 59.6 kDa	No	0
CIITA-008 ENSP00000459608 ENST00000576601	I3L2E5 [Direct mapping] MHC class II transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005524 [ATP binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	177 aa 19.7 kDa	No	0
CIITA-201 ENSP00000483487 ENST00000611587	A0A087X0L5 [Direct mapping] MHC class II transactivator Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005524 [ATP binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	884 aa 96.5 kDa	No	0
CIITA-202 ENSP00000484761 ENST00000618207	Q29704 [Direct mapping] Class II MHC mutant RJ2.2.5; MHC class II transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005524 [ATP binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	353 aa 38.2 kDa	No	0
CIITA-203 ENSP00000485010 ENST00000618327	A0A087X2I7 [Direct mapping] MHC class II transactivator Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006954 [inflammatory response] GO:0007568 [aging] GO:0009986 [cell surface] GO:0045348 [positive regulation of MHC class II biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0071257 [cellular response to electrical stimulus] GO:0071346 [cellular response to interferon-gamma] GO:0071360 [cellular response to exogenous dsRNA] Show all	1131 aa 123.5 kDa	No	0