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Most of the tumour cells displayed weak to moderate cytoplasmic and/or nuclear staining. Several lung adenocarcinomas along with a rare case each of carcinoid, papillary adenocarcinoma of thyroid, stomach and pancreatic cancer were strongly stained. Gliomas, lymphomas, skin and testis cancers were mainly negative.
GENE INFORMATION
Gene name
ZFPM1 (HGNC Symbol)
Synonyms
FOG, FOG1, ZC2HC11A, ZNF89A
Description
Zinc finger protein, FOG family member 1 (HGNC Symbol)
Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0002295 [T-helper cell lineage commitment] GO:0003151 [outflow tract morphogenesis] GO:0003181 [atrioventricular valve morphogenesis] GO:0003192 [mitral valve formation] GO:0003195 [tricuspid valve formation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] GO:0007596 [blood coagulation] GO:0008134 [transcription factor binding] GO:0010724 [regulation of definitive erythrocyte differentiation] GO:0017053 [transcriptional repressor complex] GO:0030218 [erythrocyte differentiation] GO:0030219 [megakaryocyte differentiation] GO:0030220 [platelet formation] GO:0030851 [granulocyte differentiation] GO:0032091 [negative regulation of protein binding] GO:0032642 [regulation of chemokine production] GO:0035162 [embryonic hemopoiesis] GO:0035855 [megakaryocyte development] GO:0045078 [positive regulation of interferon-gamma biosynthetic process] GO:0045403 [negative regulation of interleukin-4 biosynthetic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048872 [homeostasis of number of cells] GO:0055008 [cardiac muscle tissue morphogenesis] GO:0060318 [definitive erythrocyte differentiation] GO:0060319 [primitive erythrocyte differentiation] GO:0060377 [negative regulation of mast cell differentiation] GO:0060412 [ventricular septum morphogenesis] GO:0060413 [atrial septum morphogenesis] GO:0071733 [transcriptional activation by promoter-enhancer looping]