Expression of ZBTB42 in cancer - Summary

CANCER ATLAS

Gene description

Zinc finger and BTB domain containing 42

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000703

GENE INFORMATION
Gene name	ZBTB42 (HGNC Symbol)
Synonyms	ZNF925
Description	Zinc finger and BTB domain containing 42 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	104800596 - 104804712
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179627 (version 83.38)
Entrez gene	100128927
UniProt	B2RXF5 (UniProt - Evidence at protein level)
neXtProt	NX_B2RXF5
Antibodypedia	ZBTB42 antibodies

PROTEIN BROWSER

ZBTB42-001	ZBTB42-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZBTB42-001 ENSP00000450673 ENST00000555360	B2RXF5 [Direct mapping] Zinc finger and BTB domain-containing protein 42 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0046872 [metal ion binding] Show all	422 aa 46.5 kDa	No	0
ZBTB42-002 ENSP00000409107 ENST00000342537	B2RXF5 [Direct mapping] Zinc finger and BTB domain-containing protein 42 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0046872 [metal ion binding] Show all	422 aa 46.5 kDa	No	0