Cell atlas - ZBTB42 - The Human Protein Atlas

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ZBTB42

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZBTB42
Gene description	Zinc finger and BTB domain containing 42
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Cell line enhanced (MCF7, T-47d, HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA066961
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7, T-47d, HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066961	MCF7	Nucleoplasm
	HPA066961	RT4	Nucleus
	HPA066961	U-2 OS	Nucleus
	HPA066961	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	ZBTB42 (HGNC Symbol)
Synonyms	ZNF925
Description	Zinc finger and BTB domain containing 42 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	104800596 - 104804712
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179627 (version 83.38)
Entrez gene	100128927
UniProt	B2RXF5 (UniProt - Evidence at protein level)
neXtProt	NX_B2RXF5
Antibodypedia	ZBTB42 antibodies

PROTEIN BROWSER

ZBTB42-001	ZBTB42-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZBTB42-001 ENSP00000450673 ENST00000555360	B2RXF5 [Direct mapping] Zinc finger and BTB domain-containing protein 42 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0046872 [metal ion binding] Show all	422 aa 46.5 kDa	No	0
ZBTB42-002 ENSP00000409107 ENST00000342537	B2RXF5 [Direct mapping] Zinc finger and BTB domain-containing protein 42 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0046872 [metal ion binding] Show all	422 aa 46.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.