Expression of FCER1A in cancer - Summary

CANCER ATLAS

Gene description

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

Protein class

FDA approved drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036051	CAB022102	CAB055526

GENE INFORMATION
Gene name	FCER1A (HGNC Symbol)
Synonyms	FCE1A
Description	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (HGNC Symbol)
Entrez gene summary	The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	159289714 - 159308224
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179639 (version 83.38)
Entrez gene	2205
UniProt	P12319 (UniProt - Evidence at protein level)
neXtProt	NX_P12319
Antibodypedia	FCER1A antibodies

PROTEIN BROWSER

FCER1A-001	FCER1A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCER1A-001 ENSP00000357097 ENST00000368115	P12319 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0000187 [activation of MAPK activity] GO:0001812 [positive regulation of type I hypersensitivity] GO:0001820 [serotonin secretion] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007257 [activation of JUN kinase activity] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0019370 [leukotriene biosynthetic process] GO:0019767 [IgE receptor activity] GO:0019863 [IgE binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043306 [positive regulation of mast cell degranulation] GO:0045087 [innate immune response] GO:0045401 [positive regulation of interleukin-3 biosynthetic process] GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050850 [positive regulation of calcium-mediated signaling] Show all	257 aa 29.6 kDa	Yes	1
FCER1A-002 ENSP00000357096 ENST00000368114	E9PRN1 [Direct mapping] High affinity immunoglobulin epsilon receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	224 aa 25.8 kDa	Yes	1