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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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FCER1A
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FCER1A

Gene description

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

Protein class

FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (gallbladder)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in subsets of immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

Approved based on 3 antibodies.
HPA036051 , CAB022102 , CAB055526
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder)

GENE INFORMATION

Gene name

FCER1A (HGNC Symbol)

Synonyms

FCE1A

Description

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (HGNC Symbol)

Entrez gene summary

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

q23.2

Chromosome location (bp)

159289714 - 159308224

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179639 (version 83.38)

Entrez gene

2205

UniProt

P12319 (UniProt - Evidence at protein level)

neXtProt

NX_P12319

Antibodypedia

FCER1A antibodies

PROTEIN BROWSER

FCER1A-001
FCER1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FCER1A-001
ENSP00000357097
ENST00000368115
P12319 [Direct mapping]
High affinity immunoglobulin epsilon receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Show all
GO:0000187 [activation of MAPK activity]
GO:0001812 [positive regulation of type I hypersensitivity]
GO:0001820 [serotonin secretion]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007257 [activation of JUN kinase activity]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0019370 [leukotriene biosynthetic process]
GO:0019767 [IgE receptor activity]
GO:0019863 [IgE binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043306 [positive regulation of mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045401 [positive regulation of interleukin-3 biosynthetic process]
GO:0045425 [positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050850 [positive regulation of calcium-mediated signaling]
Show all
257 aa
29.6 kDa
Yes 1
FCER1A-002
ENSP00000357096
ENST00000368114
E9PRN1 [Direct mapping]
High affinity immunoglobulin epsilon receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
224 aa
25.8 kDa
Yes 1

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