Expression of GPBAR1 in cancer - Summary

CANCER ATLAS

Gene description

G protein-coupled bile acid receptor 1

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA062890

GENE INFORMATION
Gene name	GPBAR1 (HGNC Symbol)
Synonyms	BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5
Description	G protein-coupled bile acid receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218259496 - 218263859
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000179921 (version 83.38)
Entrez gene	151306
UniProt	Q8TDU6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDU6
Antibodypedia	GPBAR1 antibodies

PROTEIN BROWSER

GPBAR1-001	GPBAR1-002	GPBAR1-003	GPBAR1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPBAR1-001 ENSP00000430698 ENST00000479077	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] Show all	330 aa 35.2 kDa	No	7
GPBAR1-002 ENSP00000430886 ENST00000522678	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] GO:2000810 [regulation of bicellular tight junction assembly] Show all	330 aa 35.2 kDa	No	7
GPBAR1-003 ENSP00000430202 ENST00000519574	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] Show all	330 aa 35.2 kDa	No	7
GPBAR1-004 ENSP00000428824 ENST00000521462	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] Show all	330 aa 35.2 kDa	No	7