Tissue expression of GPBAR1 - Summary - The Human Protein Atlas

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GPBAR1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GPBAR1
Gene description	G protein-coupled bile acid receptor 1
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (gallbladder, smooth muscle)
GTEx:	Tissue enhanced (adipose tissue, breast)
FANTOM5:	Tissue enriched (gallbladder)

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA062890
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder, smooth muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, breast)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (gallbladder)

GENE INFORMATION
Gene name	GPBAR1 (HGNC Symbol)
Synonyms	BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5
Description	G protein-coupled bile acid receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218259496 - 218263859
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000179921 (version 83.38)
Entrez gene	151306
UniProt	Q8TDU6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDU6
Antibodypedia	GPBAR1 antibodies

PROTEIN BROWSER

GPBAR1-001	GPBAR1-002	GPBAR1-003	GPBAR1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPBAR1-001 ENSP00000430698 ENST00000479077	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] Show all	330 aa 35.2 kDa	No	7
GPBAR1-002 ENSP00000430886 ENST00000522678	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] GO:2000810 [regulation of bicellular tight junction assembly] Show all	330 aa 35.2 kDa	No	7
GPBAR1-003 ENSP00000430202 ENST00000519574	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] Show all	330 aa 35.2 kDa	No	7
GPBAR1-004 ENSP00000428824 ENST00000521462	Q8TDU6 [Direct mapping] G-protein coupled bile acid receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0038181 [bile acid receptor activity] GO:0038182 [G-protein coupled bile acid receptor activity] GO:0038184 [cell surface bile acid receptor signaling pathway] Show all	330 aa 35.2 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.