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NRIP1

CANCER ATLAS

Gene description

 Nuclear receptor interacting protein 1

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046571

GENE INFORMATION

Gene name

 NRIP1 (HGNC Symbol)

Synonyms

 RIP140

Description

 Nuclear receptor interacting protein 1 (HGNC Symbol)

Entrez gene summary

 Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

Chromosome location (bp)

 14961235 - 15065000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180530 (version 83.38)

Entrez gene

 8204

UniProt

 P48552 (UniProt - Evidence at protein level)

neXtProt

 NX_P48552

Antibodypedia

 NRIP1 antibodies

PROTEIN BROWSER
NRIP1-001
NRIP1-002
NRIP1-004
NRIP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRIP1-001
ENSP00000383060
ENST00000400199
P48552 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0030054 [cell junction]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0035259 [glucocorticoid receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050681 [androgen receptor binding]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 1158 aa
126.9 kDa 		No 0
NRIP1-002
ENSP00000383063
ENST00000400202
P48552 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001543 [ovarian follicle rupture]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0016607 [nuclear speck]
GO:0019915 [lipid storage]
GO:0030054 [cell junction]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0030728 [ovulation]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0035259 [glucocorticoid receptor binding]
GO:0042826 [histone deacetylase binding]
GO:0042974 [retinoic acid receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0050681 [androgen receptor binding]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 1158 aa
126.9 kDa 		No 0
NRIP1-004
ENSP00000412114
ENST00000411932
C9J130 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 66 aa
6.9 kDa 		No 0
NRIP1-201
ENSP00000327213
ENST00000318948
P48552 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0030054 [cell junction]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0035259 [glucocorticoid receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050681 [androgen receptor binding]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 1158 aa
126.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.