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NRIP1

GENERAL INFORMATION

Gene name

 NRIP1

Gene description

 Nuclear receptor interacting protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046571
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NRIP1 (HGNC Symbol)

Synonyms

 RIP140

Description

 Nuclear receptor interacting protein 1 (HGNC Symbol)

Entrez gene summary

 Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

Chromosome location (bp)

 14961235 - 15065000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180530 (version 83.38)

Entrez gene

 8204

UniProt

 P48552 (UniProt - Evidence at protein level)

neXtProt

 NX_P48552

Antibodypedia

 NRIP1 antibodies

PROTEIN BROWSER
NRIP1-001
NRIP1-002
NRIP1-004
NRIP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NRIP1-001
ENSP00000383060
ENST00000400199
P48552 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0030054 [cell junction]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0035259 [glucocorticoid receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050681 [androgen receptor binding]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 1158 aa
126.9 kDa 		No 0
NRIP1-002
ENSP00000383063
ENST00000400202
P48552 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001543 [ovarian follicle rupture]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0016607 [nuclear speck]
GO:0019915 [lipid storage]
GO:0030054 [cell junction]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0030728 [ovulation]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0035259 [glucocorticoid receptor binding]
GO:0042826 [histone deacetylase binding]
GO:0042974 [retinoic acid receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0050681 [androgen receptor binding]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 1158 aa
126.9 kDa 		No 0
NRIP1-004
ENSP00000412114
ENST00000411932
C9J130 [Direct mapping]
Nuclear receptor-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 66 aa
6.9 kDa 		No 0
NRIP1-201
ENSP00000327213
ENST00000318948
P48552 [Direct mapping]
Nuclear receptor-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0030054 [cell junction]
GO:0030331 [estrogen receptor binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0035259 [glucocorticoid receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050681 [androgen receptor binding]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 1158 aa
126.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.