Expression of SLC36A4 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 36 (proton/amino acid symporter), member 4

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017887

GENE INFORMATION
Gene name	SLC36A4 (HGNC Symbol)
Synonyms	FLJ38932, PAT4
Description	Solute carrier family 36 (proton/amino acid symporter), member 4 (HGNC Symbol)
Entrez gene summary	SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]
Chromosome	11
Cytoband	q21
Chromosome location (bp)	93144171 - 93197964
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180773 (version 83.38)
Entrez gene	120103
UniProt	Q6YBV0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6YBV0
Antibodypedia	SLC36A4 antibodies

PROTEIN BROWSER

SLC36A4-001	SLC36A4-002	SLC36A4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC36A4-001 ENSP00000317382 ENST00000326402	Q6YBV0 [Direct mapping] Proton-coupled amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005774 [vacuolar membrane] GO:0015171 [amino acid transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015196 [L-tryptophan transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015808 [L-alanine transport] GO:0015824 [proline transport] GO:0015827 [tryptophan transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] Show all	504 aa 56.2 kDa	No	>9
SLC36A4-002 ENSP00000436570 ENST00000529184	Q6YBV0 [Direct mapping] Proton-coupled amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005774 [vacuolar membrane] GO:0015171 [amino acid transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015196 [L-tryptophan transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015808 [L-alanine transport] GO:0015824 [proline transport] GO:0015827 [tryptophan transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] Show all	369 aa 41.4 kDa	No	9
SLC36A4-004 ENSP00000432061 ENST00000534116	E9PID7 [Direct mapping] Proton-coupled amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005774 [vacuolar membrane] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] Show all	280 aa 32 kDa	No	6