Cell atlas - SLC36A4 - The Human Protein Atlas

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SLC36A4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Plasma membrane

Human cell
	Cytosol
	Golgi Apparatus
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SLC36A4
Gene description	Solute carrier family 36 (proton/amino acid symporter), member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, cytosol & the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017887
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, cytosol & the Golgi apparatus.

Main location

Golgi apparatus (approved), Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017887	A-431	Golgi apparatus
			Plasma membrane
			Cytosol
	HPA017887	U-2 OS	Golgi apparatus
			Plasma membrane
			Cytosol
	HPA017887	U-251 MG	Golgi apparatus
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	SLC36A4 (HGNC Symbol)
Synonyms	FLJ38932, PAT4
Description	Solute carrier family 36 (proton/amino acid symporter), member 4 (HGNC Symbol)
Entrez gene summary	SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]
Chromosome	11
Cytoband	q21
Chromosome location (bp)	93144171 - 93197964
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180773 (version 83.38)
Entrez gene	120103
UniProt	Q6YBV0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6YBV0
Antibodypedia	SLC36A4 antibodies

PROTEIN BROWSER

SLC36A4-001	SLC36A4-002	SLC36A4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC36A4-001 ENSP00000317382 ENST00000326402	Q6YBV0 [Direct mapping] Proton-coupled amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005774 [vacuolar membrane] GO:0015171 [amino acid transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015196 [L-tryptophan transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015808 [L-alanine transport] GO:0015824 [proline transport] GO:0015827 [tryptophan transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] Show all	504 aa 56.2 kDa	No	>9
SLC36A4-002 ENSP00000436570 ENST00000529184	Q6YBV0 [Direct mapping] Proton-coupled amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005774 [vacuolar membrane] GO:0015171 [amino acid transmembrane transporter activity] GO:0015180 [L-alanine transmembrane transporter activity] GO:0015193 [L-proline transmembrane transporter activity] GO:0015196 [L-tryptophan transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015808 [L-alanine transport] GO:0015824 [proline transport] GO:0015827 [tryptophan transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] Show all	369 aa 41.4 kDa	No	9
SLC36A4-004 ENSP00000432061 ENST00000534116	E9PID7 [Direct mapping] Proton-coupled amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0005774 [vacuolar membrane] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] Show all	280 aa 32 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.