Expression of PPA1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Pyrophosphatase (inorganic) 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019878	HPA020096

GENE INFORMATION
Gene name	PPA1 (HGNC Symbol)
Synonyms	IOPPP, PP, PP1, Ppase, SID6-8061
Description	Pyrophosphatase (inorganic) 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70202830 - 70233911
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180817 (version 83.38)
Entrez gene	5464
UniProt	Q15181 (UniProt - Evidence at protein level)
neXtProt	NX_Q15181
Antibodypedia	PPA1 antibodies

PROTEIN BROWSER

PPA1-001	PPA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPA1-001 ENSP00000362329 ENST00000373232	Q15181 [Direct mapping] Inorganic pyrophosphatase V9HWB5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 66p; Pyrophosphatase (Inorganic) 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006796 [phosphate-containing compound metabolic process] GO:0010467 [gene expression] GO:0016462 [pyrophosphatase activity] GO:0070062 [extracellular exosome] GO:0071344 [diphosphate metabolic process] Show all	289 aa 32.7 kDa	No	0
PPA1-201 ENSP00000486162 ENST00000625364	Q5SQT6 [Direct mapping] Inorganic pyrophosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	178 aa 20 kDa	No	0