Cell atlas - PPA1 - The Human Protein Atlas

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PPA1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PPA1
Gene description	Pyrophosphatase (inorganic) 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA020096
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA020096	A-431	Vesicles
	HPA020096	U-2 OS	Vesicles
	HPA020096	U-251 MG	Vesicles

GENE INFORMATION
Gene name	PPA1 (HGNC Symbol)
Synonyms	IOPPP, PP, PP1, Ppase, SID6-8061
Description	Pyrophosphatase (inorganic) 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70202830 - 70233911
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180817 (version 83.38)
Entrez gene	5464
UniProt	Q15181 (UniProt - Evidence at protein level)
neXtProt	NX_Q15181
Antibodypedia	PPA1 antibodies

PROTEIN BROWSER

PPA1-001	PPA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPA1-001 ENSP00000362329 ENST00000373232	Q15181 [Direct mapping] Inorganic pyrophosphatase V9HWB5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 66p; Pyrophosphatase (Inorganic) 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006796 [phosphate-containing compound metabolic process] GO:0010467 [gene expression] GO:0016462 [pyrophosphatase activity] GO:0070062 [extracellular exosome] GO:0071344 [diphosphate metabolic process] Show all	289 aa 32.7 kDa	No	0
PPA1-201 ENSP00000486162 ENST00000625364	Q5SQT6 [Direct mapping] Inorganic pyrophosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	178 aa 20 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.