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PITPNB

GENERAL INFORMATION

Gene name

 PITPNB

Gene description

 Phosphatidylinositol transfer protein, beta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in squamous epithelia and subsets of stromal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA000528
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PITPNB (HGNC Symbol)

Synonyms

 VIB1B

Description

 Phosphatidylinositol transfer protein, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 22

Cytoband

 q12.1

Chromosome location (bp)

 27851669 - 27920134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180957 (version 83.38)

Entrez gene

 23760

UniProt

 P48739 (UniProt - Evidence at protein level)

neXtProt

 NX_P48739

Antibodypedia

 PITPNB antibodies

PROTEIN BROWSER
PITPNB-001
PITPNB-002
PITPNB-003
PITPNB-006
PITPNB-012
PITPNB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PITPNB-001
ENSP00000334738
ENST00000335272
P48739 [Direct mapping]
Phosphatidylinositol transfer protein beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0015914 [phospholipid transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 271 aa
31.5 kDa 		No 0
PITPNB-002
ENSP00000321266
ENST00000320996
P48739 [Direct mapping]
Phosphatidylinositol transfer protein beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001701 [in utero embryonic development]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0015914 [phospholipid transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 272 aa
31.6 kDa 		No 0
PITPNB-003
ENSP00000406542
ENST00000415296
B3KYB6 [Direct mapping]
Phosphatidylinositol transfer protein beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 120 aa
13.8 kDa 		No 0
PITPNB-006
ENSP00000403675
ENST00000436663
B3KYB7 [Direct mapping]
Phosphatidylinositol transfer protein beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 168 aa
19.2 kDa 		No 0
PITPNB-012
ENSP00000487693
ENST00000634017
P48739 [Direct mapping]
Phosphatidylinositol transfer protein beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005622 [intracellular]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0015914 [phospholipid transport]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 273 aa
31.7 kDa 		No 0
PITPNB-201
ENSP00000405179
ENST00000455418
A0A0A0MSW4 [Direct mapping]
Phosphatidylinositol transfer protein beta isoform
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 271 aa
31.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.