Expression of DHTKD1 in cancer - Summary

CANCER ATLAS

Gene description

Dehydrogenase E1 and transketolase domain containing 1

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA037949	HPA037950	HPA066098

GENE INFORMATION
Gene name	DHTKD1 (HGNC Symbol)
Synonyms	CMT2Q, DKFZP762M115, KIAA1630, MGC3090
Description	Dehydrogenase E1 and transketolase domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013]
Chromosome	10
Cytoband	p14
Chromosome location (bp)	12068972 - 12123225
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181192 (version 83.38)
Entrez gene	55526
UniProt	Q96HY7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HY7
Antibodypedia	DHTKD1 antibodies

PROTEIN BROWSER

DHTKD1-001	DHTKD1-003	DHTKD1-004	DHTKD1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHTKD1-001 ENSP00000263035 ENST00000263035	Q96HY7 [Direct mapping] Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002244 [hematopoietic progenitor cell differentiation] GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity] GO:0005739 [mitochondrion] GO:0006091 [generation of precursor metabolites and energy] GO:0006096 [glycolytic process] GO:0006099 [tricarboxylic acid cycle] GO:0008152 [metabolic process] GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor] GO:0030976 [thiamine pyrophosphate binding] GO:0045252 [oxoglutarate dehydrogenase complex] GO:0055114 [oxidation-reduction process] Show all	919 aa 103.1 kDa	No	0
DHTKD1-003 ENSP00000398482 ENST00000448829	H7C149 [Direct mapping] Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity] GO:0006099 [tricarboxylic acid cycle] GO:0030976 [thiamine pyrophosphate binding] GO:0045252 [oxoglutarate dehydrogenase complex] Show all	214 aa 23.7 kDa	No	0
DHTKD1-004 ENSP00000400625 ENST00000415935	H7C1J3 [Direct mapping] Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity] GO:0006099 [tricarboxylic acid cycle] GO:0008152 [metabolic process] GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor] GO:0030976 [thiamine pyrophosphate binding] GO:0045252 [oxoglutarate dehydrogenase complex] Show all	161 aa 18.3 kDa	No	0
DHTKD1-006 ENSP00000388163 ENST00000437298	C9JWN1 [Direct mapping] Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0008152 [metabolic process] GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor] GO:0030976 [thiamine pyrophosphate binding] GO:0045252 [oxoglutarate dehydrogenase complex] Show all	308 aa 34.3 kDa	No	0