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Most prostate and liver cancers along with several pancreas and ovarian cancers as well as a few endometrial, renal and gastric cancer displayed moderate to strong cytoplasmic staining, with granular patter. Remaining cancer tissues were mainly weakly stained or negative.
This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]