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EXOC7

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GENERAL INFORMATION

Gene name

 EXOC7

Gene description

 Exocyst complex component 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Vesicles (approved), Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA022840
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane & vesicles.

Main location

 Cytosol (approved)

Additional location

 Vesicles (approved), Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA022840 A-431 Plasma membrane
Cytosol
HPA022840 U-2 OS Vesicles
Cytosol
HPA022840 U-251 MG Cytosol

GENE INFORMATION

Gene name

 EXOC7 (HGNC Symbol)

Synonyms

 EXO70, Exo70p, KIAA1067, YJL085W

Description

 Exocyst complex component 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76081017 - 76121576

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182473 (version 83.38)

Entrez gene

 23265

UniProt

 Q9UPT5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPT5

Antibodypedia

 EXOC7 antibodies

PROTEIN BROWSER
«
EXOC7-001
EXOC7-002
EXOC7-004
EXOC7-006
EXOC7-011
EXOC7-012
EXOC7-013
EXOC7-018
EXOC7-019
EXOC7-020
EXOC7-021
EXOC7-024
EXOC7-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOC7-001
ENSP00000468404
ENST00000589210
Q9UPT5 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0034451 [centriolar satellite]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
GO:2000535 [regulation of entry of bacterium into host cell]
Show all
 684 aa
78.1 kDa 		No 0
EXOC7-002
ENSP00000384368
ENST00000405575
A0A0A0MSB8 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 693 aa
78.8 kDa 		No 0
EXOC7-004
ENSP00000385066
ENST00000406660
B5MCY9 [Direct mapping]
Exocyst complex component 7; Exocyst complex component 7, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 159 aa
18.1 kDa 		No 0
EXOC7-006
ENSP00000334100
ENST00000335146
Q9UPT5 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032584 [growth cone membrane]
GO:0034451 [centriolar satellite]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
GO:2000535 [regulation of entry of bacterium into host cell]
Show all
 735 aa
83.4 kDa 		No 0
EXOC7-011
ENSP00000389723
ENST00000442951
C9JME6 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 121 aa
13.9 kDa 		No 0
EXOC7-012
ENSP00000389950
ENST00000420116
C9JKC2 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 122 aa
14.2 kDa 		No 0
EXOC7-013
ENSP00000404322
ENST00000411744
Q9UPT5 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0034451 [centriolar satellite]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
GO:2000535 [regulation of entry of bacterium into host cell]
Show all
 676 aa
77.3 kDa 		No 0
EXOC7-018
ENSP00000466682
ENST00000467929
B4DJ07 [Direct mapping]
Exocyst complex component 7; cDNA FLJ58532, highly similar to Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 656 aa
74.7 kDa 		No 0
EXOC7-019
ENSP00000333806
ENST00000332065
Q9UPT5 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0034451 [centriolar satellite]
GO:0044267 [cellular protein metabolic process]
GO:0061024 [membrane organization]
GO:2000535 [regulation of entry of bacterium into host cell]
Show all
 653 aa
74.7 kDa 		No 0
EXOC7-020
ENSP00000349767
ENST00000357231
A0A0A0MRE1 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 617 aa
70.2 kDa 		No 0
EXOC7-021
ENSP00000468364
ENST00000589507
K7ERQ5 [Direct mapping]
Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 168 aa
19.4 kDa 		No 0
EXOC7-024
ENSP00000489266
ENST00000634349
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 707 aa
80.6 kDa 		No 0
EXOC7-201
ENSP00000475431
ENST00000607838
B4DJ07 [Direct mapping]
Exocyst complex component 7; cDNA FLJ58532, highly similar to Exocyst complex component 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0006887 [exocytosis]
Show all
 656 aa
74.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.