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PLCB1

GENERAL INFORMATION

Gene name

 PLCB1

Gene description

 Phospholipase C, beta 1 (phosphoinositide-specific)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland, cerebral cortex)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA034743 , HPA057910 , CAB004275 , CAB005334
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PLCB1 (HGNC Symbol)

Synonyms

 KIAA0581, PLC-I, PLC154

Description

 Phospholipase C, beta 1 (phosphoinositide-specific) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p12.3

Chromosome location (bp)

 8114453 - 8968360

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182621 (version 83.38)

Entrez gene

 23236

UniProt

 Q9NQ66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQ66

Antibodypedia

 PLCB1 antibodies

PROTEIN BROWSER
«
PLCB1-001
PLCB1-003
PLCB1-004
PLCB1-005
PLCB1-007
PLCB1-008
PLCB1-009
PLCB1-010
PLCB1-012
PLCB1-013
PLCB1-014
PLCB1-016
PLCB1-201
PLCB1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCB1-001
ENSP00000486531
ENST00000629992
A0A0D9SFE7 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 248 aa
28 kDa 		No 0
PLCB1-003
ENSP00000338185
ENST00000338037
Q9NQ66 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005521 [lamin binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007613 [memory]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0016042 [lipid catabolic process]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0021987 [cerebral cortex development]
GO:0031965 [nuclear membrane]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035556 [intracellular signal transduction]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0040019 [positive regulation of embryonic development]
GO:0042803 [protein homodimerization activity]
GO:0043209 [myelin sheath]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045444 [fat cell differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046330 [positive regulation of JNK cascade]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048639 [positive regulation of developmental growth]
GO:0060466 [activation of meiosis involved in egg activation]
GO:0070062 [extracellular exosome]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0080154 [regulation of fertilization]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000344 [positive regulation of acrosome reaction]
GO:2000438 [negative regulation of monocyte extravasation]
GO:2000560 [positive regulation of CD24 biosynthetic process]
Show all
 1216 aa
138.6 kDa 		No 0
PLCB1-004
ENSP00000367904
ENST00000378637
Q9NQ66 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007613 [memory]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0016042 [lipid catabolic process]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0021987 [cerebral cortex development]
GO:0031965 [nuclear membrane]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035556 [intracellular signal transduction]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0040019 [positive regulation of embryonic development]
GO:0042803 [protein homodimerization activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046330 [positive regulation of JNK cascade]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048639 [positive regulation of developmental growth]
GO:0060466 [activation of meiosis involved in egg activation]
GO:0070062 [extracellular exosome]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0080154 [regulation of fertilization]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000344 [positive regulation of acrosome reaction]
GO:2000438 [negative regulation of monocyte extravasation]
GO:2000560 [positive regulation of CD24 biosynthetic process]
Show all
 1173 aa
133.7 kDa 		No 0
PLCB1-005
ENSP00000367908
ENST00000378641
Q9NQ66 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007613 [memory]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0016042 [lipid catabolic process]
GO:0016607 [nuclear speck]
GO:0019899 [enzyme binding]
GO:0021987 [cerebral cortex development]
GO:0031965 [nuclear membrane]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035556 [intracellular signal transduction]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0035723 [interleukin-15-mediated signaling pathway]
GO:0040019 [positive regulation of embryonic development]
GO:0042803 [protein homodimerization activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046330 [positive regulation of JNK cascade]
GO:0046488 [phosphatidylinositol metabolic process]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048639 [positive regulation of developmental growth]
GO:0060466 [activation of meiosis involved in egg activation]
GO:0070062 [extracellular exosome]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0080154 [regulation of fertilization]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000344 [positive regulation of acrosome reaction]
GO:2000438 [negative regulation of monocyte extravasation]
GO:2000560 [positive regulation of CD24 biosynthetic process]
Show all
 1173 aa
133.7 kDa 		No 0
PLCB1-007
ENSP00000391162
ENST00000439627
Q8IV92 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 196 aa
22.3 kDa 		No 0
PLCB1-008
ENSP00000389911
ENST00000437439
Q8IV91 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 41 aa
5 kDa 		No 0
PLCB1-009
ENSP00000486428
ENST00000475958
A0A0D9SFA6 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 26 aa
2.9 kDa 		No 0
PLCB1-010
ENSP00000487544
ENST00000628239
A0A0D9SGI7 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 231 aa
27.7 kDa 		No 0
PLCB1-012
ENSP00000384001
ENST00000404098
B1AK73 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 205 aa
23.1 kDa 		No 0
PLCB1-013
ENSP00000486301
ENST00000625874
A0A0D9SF51 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007420 [brain development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 960 aa
109.1 kDa 		No 0
PLCB1-014
ENSP00000487075
ENST00000626966
A0A0D9SG17 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007420 [brain development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 961 aa
109.2 kDa 		No 0
PLCB1-016
ENSP00000486655
ENST00000630495
A0A0D9SFJ4 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 137 aa
15.6 kDa 		No 0
PLCB1-201
ENSP00000479997
ENST00000612075
A0A087WW73 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007420 [brain development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 1093 aa
124.8 kDa 		No 0
PLCB1-202
ENSP00000477664
ENST00000617005
A0A087WT80 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007420 [brain development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0051726 [regulation of cell cycle]
Show all
 1136 aa
129.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.