Expression of GALR2 in cancer - Summary

CANCER ATLAS

Gene description

Galanin receptor 2

Protein class

G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044513

GENE INFORMATION
Gene name	GALR2 (HGNC Symbol)
Synonyms	GALNR2
Description	Galanin receptor 2 (HGNC Symbol)
Entrez gene summary	Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	76074794 - 76077541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182687 (version 83.38)
Entrez gene	8811
UniProt	O43603 (UniProt - Evidence at protein level)
neXtProt	NX_O43603
Antibodypedia	GALR2 antibodies

PROTEIN BROWSER

GALR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GALR2-001 ENSP00000329684 ENST00000329003	O43603 [Direct mapping] Galanin receptor type 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004966 [galanin receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0007275 [multicellular organismal development] GO:0007586 [digestion] GO:0007611 [learning or memory] GO:0007631 [feeding behavior] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031175 [neuron projection development] GO:0042923 [neuropeptide binding] GO:0043647 [inositol phosphate metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046488 [phosphatidylinositol metabolic process] GO:1902608 [positive regulation of large conductance calcium-activated potassium channel activity] Show all	387 aa 41.7 kDa	No	7