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GALR2

GENERAL INFORMATION

Gene name

 GALR2

Gene description

 Galanin receptor 2

Protein class

 G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (smooth muscle)
GTEx:Group enriched (colon, small intestine)
FANTOM5:Group enriched (colon, appendix, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membrane expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044513
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, appendix, small intestine)

GENE INFORMATION

Gene name

 GALR2 (HGNC Symbol)

Synonyms

 GALNR2

Description

 Galanin receptor 2 (HGNC Symbol)

Entrez gene summary

 Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76074794 - 76077541

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182687 (version 83.38)

Entrez gene

 8811

UniProt

 O43603 (UniProt - Evidence at protein level)

neXtProt

 NX_O43603

Antibodypedia

 GALR2 antibodies

PROTEIN BROWSER
GALR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GALR2-001
ENSP00000329684
ENST00000329003
O43603 [Direct mapping]
Galanin receptor type 2
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
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GO:0004930 [G-protein coupled receptor activity]
GO:0004966 [galanin receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006936 [muscle contraction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007275 [multicellular organismal development]
GO:0007586 [digestion]
GO:0007611 [learning or memory]
GO:0007631 [feeding behavior]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0031175 [neuron projection development]
GO:0042923 [neuropeptide binding]
GO:0043647 [inositol phosphate metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046488 [phosphatidylinositol metabolic process]
GO:1902608 [positive regulation of large conductance calcium-activated potassium channel activity]
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 387 aa
41.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.