Expression of HOXB4 in cancer - Summary

CANCER ATLAS

Gene description

Homeobox B4

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA057432

GENE INFORMATION
Gene name	HOXB4 (HGNC Symbol)
Synonyms	HOX2, HOX2F
Description	Homeobox B4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48575513 - 48580111
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000182742 (version 83.38)
Entrez gene	3214
UniProt	P17483 (UniProt - Evidence at transcript level)
neXtProt	NX_P17483
Antibodypedia	HOXB4 antibodies

PROTEIN BROWSER

HOXB4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXB4-001 ENSP00000328928 ENST00000332503	P17483 [Direct mapping] Homeobox protein Hox-B4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002011 [morphogenesis of an epithelial sheet] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008283 [cell proliferation] GO:0009952 [anterior/posterior pattern specification] GO:0030097 [hemopoiesis] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048103 [somatic stem cell division] GO:0048536 [spleen development] GO:0048539 [bone marrow development] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048705 [skeletal system morphogenesis] GO:0060216 [definitive hemopoiesis] GO:0060218 [hematopoietic stem cell differentiation] GO:2000738 [positive regulation of stem cell differentiation] Show all	251 aa 27.6 kDa	No	0