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HOXB4

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GENERAL INFORMATION

Gene name

 HOXB4

Gene description

 Homeobox B4

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & centrosome.

RNA cell category

 Cell line enhanced (EFO-21, HMC-1)

Protein evidence

 Evidence at transcript level

Main location

 Localized to the Nucleus (approved), Centrosome (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA057432
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & centrosome.

Main location

 Nucleus (approved), Centrosome (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057432 HEK 293 Nucleus
Centrosome
HPA057432 RH-30 No staining    
HPA057432 U-2 OS No staining    

GENE INFORMATION

Gene name

 HOXB4 (HGNC Symbol)

Synonyms

 HOX2, HOX2F

Description

 Homeobox B4 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48575513 - 48580111

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000182742 (version 83.38)

Entrez gene

 3214

UniProt

 P17483 (UniProt - Evidence at transcript level)

neXtProt

 NX_P17483

Antibodypedia

 HOXB4 antibodies

PROTEIN BROWSER
HOXB4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXB4-001
ENSP00000328928
ENST00000332503
P17483 [Direct mapping]
Homeobox protein Hox-B4
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
GO:0009952 [anterior/posterior pattern specification]
GO:0030097 [hemopoiesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048103 [somatic stem cell division]
GO:0048536 [spleen development]
GO:0048539 [bone marrow development]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0060216 [definitive hemopoiesis]
GO:0060218 [hematopoietic stem cell differentiation]
GO:2000738 [positive regulation of stem cell differentiation]
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 251 aa
27.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.