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Cancer cells generally showed weak to moderate nuclear immunoreactivity. A few testicular cancers were strongly stained. Most cervical, ovarian and prostate cancers were negative.
Gliomas showed moderate to strong nuclear immunoreactivity. Other cancer tissues were i general weakly stained or negative.
GENE INFORMATION
Gene name
MTA1
Synonyms
Description
Metastasis associated 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Q13330 [Direct mapping] Metastasis-associated protein MTA1
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Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001046 [core promoter sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006302 [double-strand break repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010212 [response to ionizing radiation] GO:0016581 [NuRD complex] GO:0032496 [response to lipopolysaccharide] GO:0032922 [circadian regulation of gene expression] GO:0040029 [regulation of gene expression, epigenetic] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045475 [locomotor rhythm] GO:0050727 [regulation of inflammatory response] GO:1902499 [positive regulation of protein autoubiquitination] GO:1903507 [negative regulation of nucleic acid-templated transcription]
