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MTA1

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GENERAL INFORMATION

Gene name

 MTA1

Gene description

 Metastasis associated 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB004508 , HPA005544
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB004508 A-431 Nucleoplasm
CAB004508 U-2 OS Nucleoplasm
CAB004508 U-251 MG Nucleoplasm
HPA005544 A-431 Nucleoplasm
Vesicles
HPA005544 U-2 OS Nucleoplasm
Cytosol
HPA005544 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 MTA1

Synonyms

Description

 Metastasis associated 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 105419820 - 105470729

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182979 (version 83.38)

Entrez gene

 9112

UniProt

 Q13330 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13330

Antibodypedia

 MTA1 antibodies

PROTEIN BROWSER
MTA1-001
MTA1-002
MTA1-003
MTA1-007
MTA1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTA1-001
ENSP00000333633
ENST00000331320
Q13330 [Direct mapping]
Metastasis-associated protein MTA1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010212 [response to ionizing radiation]
GO:0016581 [NuRD complex]
GO:0032496 [response to lipopolysaccharide]
GO:0032922 [circadian regulation of gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045475 [locomotor rhythm]
GO:0050727 [regulation of inflammatory response]
GO:1902499 [positive regulation of protein autoubiquitination]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 715 aa
80.8 kDa 		No 0
MTA1-002
ENSP00000385702
ENST00000406191
E7ESY4 [Direct mapping]
Metastasis-associated protein MTA1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
Show all
 703 aa
79.4 kDa 		No 0
MTA1-003
ENSP00000384180
ENST00000405646
Q13330 [Direct mapping]
Metastasis-associated protein MTA1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010212 [response to ionizing radiation]
GO:0032496 [response to lipopolysaccharide]
GO:0032922 [circadian regulation of gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045475 [locomotor rhythm]
GO:0050727 [regulation of inflammatory response]
GO:1902499 [positive regulation of protein autoubiquitination]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 698 aa
79.2 kDa 		No 0
MTA1-007
ENSP00000394106
ENST00000434050
H0Y4T7 [Direct mapping]
Metastasis-associated protein MTA1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
Show all
 511 aa
57.3 kDa 		No 0
MTA1-201
ENSP00000389425
ENST00000435036
F8W9Y9 [Direct mapping]
Metastasis-associated protein MTA1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 255 aa
28.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.