Expression of SLC25A21 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 25 (mitochondrial oxoadipate carrier), member 21

Protein class

Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000662

GENE INFORMATION
Gene name	SLC25A21 (HGNC Symbol)
Synonyms	ODC, ODC1
Description	Solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 (HGNC Symbol)
Entrez gene summary	SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
Chromosome	14
Cytoband	q13.3
Chromosome location (bp)	36677921 - 37172866
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183032 (version 83.38)
Entrez gene	89874
UniProt	Q9BQT8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQT8
Antibodypedia	SLC25A21 antibodies

PROTEIN BROWSER

SLC25A21-001	SLC25A21-004	SLC25A21-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A21-001 ENSP00000329452 ENST00000331299	Q9BQT8 [Direct mapping] Mitochondrial 2-oxodicarboxylate carrier Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006554 [lysine catabolic process] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	299 aa 33.3 kDa	No	0
SLC25A21-004 ENSP00000451873 ENST00000555449	Q9BQT8 [Direct mapping] Mitochondrial 2-oxodicarboxylate carrier Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006554 [lysine catabolic process] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	298 aa 33.1 kDa	No	0
SLC25A21-201 ENSP00000481445 ENST00000622765	A0A087WY12 [Direct mapping] Mitochondrial 2-oxodicarboxylate carrier Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	234 aa 26.1 kDa	No	0