Cell atlas - SLC25A10 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC25A10
Gene description	Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA023048
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Mitochondria (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA023048	A-431	Mitochondria
HPA023048	U-2 OS	Mitochondria
HPA023048	U-251 MG	Nucleoplasm
HPA023048	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	SLC25A10 (HGNC Symbol)
Synonyms	DIC
Description	Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81712236 - 81721016
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183048 (version 83.38)
Entrez gene	1468
UniProt	Q9UBX3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBX3
Antibodypedia	SLC25A10 antibodies

PROTEIN BROWSER

SLC25A10-001	SLC25A10-002	SLC25A10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A10-001 ENSP00000328403 ENST00000331531	Q9UBX3 [Direct mapping] Mitochondrial dicarboxylate carrier Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0005310 [dicarboxylic acid transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0006839 [mitochondrial transport] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase] Show all	296 aa 32.1 kDa	No	3
SLC25A10-002 ENSP00000345580 ENST00000350690	Q9UBX3 [Direct mapping] Mitochondrial dicarboxylate carrier Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0005310 [dicarboxylic acid transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0006839 [mitochondrial transport] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070221 [sulfide oxidation, using sulfide:quinone oxidoreductase] Show all	287 aa 31.3 kDa	No	0
SLC25A10-201 ENSP00000446242 ENST00000545862	F6RGN5 [Direct mapping] Mitochondrial dicarboxylate carrier Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	406 aa 43.6 kDa	No	0