Cell atlas - ARHGEF37 - The Human Protein Atlas

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ARHGEF37

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ARHGEF37
Gene description	Rho guanine nucleotide exchange factor (GEF) 37
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (hTCEpi, HaCaT, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053487
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, HaCaT, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053487	HaCaT	Cytosol
	HPA053487	SH-SY5Y	Cytosol
	HPA053487	U-2 OS	No staining

GENE INFORMATION
Gene name	ARHGEF37 (HGNC Symbol)
Synonyms	FLJ41603
Description	Rho guanine nucleotide exchange factor (GEF) 37 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q32
Chromosome location (bp)	149551947 - 149634968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183111 (version 83.38)
Entrez gene	389337
UniProt	A1IGU5 (UniProt - Evidence at transcript level)
neXtProt	NX_A1IGU5
Antibodypedia	ARHGEF37 antibodies

PROTEIN BROWSER

ARHGEF37-001	ARHGEF37-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF37-001 ENSP00000328083 ENST00000333677	A1IGU5 [Direct mapping] Rho guanine nucleotide exchange factor 37 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	675 aa 76.3 kDa	No	0
ARHGEF37-002 ENSP00000425621 ENST00000505810	D6RJH4 [Direct mapping] Rho guanine nucleotide exchange factor 37 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	103 aa 11.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.