Expression of PTGDR2 in cancer - Summary

CANCER ATLAS

Gene description

Prostaglandin D2 receptor 2

Protein class

CD markers, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014259

GENE INFORMATION
Gene name	PTGDR2 (HGNC Symbol)
Synonyms	CD294, CRTH2, DP2, GPR44
Description	Prostaglandin D2 receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60850940 - 60855971
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183134 (version 83.38)
Entrez gene	11251
UniProt	Q9Y5Y4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Y4
Antibodypedia	PTGDR2 antibodies

PROTEIN BROWSER

PTGDR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGDR2-001 ENSP00000332812 ENST00000332539	Q9Y5Y4 [Direct mapping] Prostaglandin D2 receptor 2 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001785 [prostaglandin J receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004956 [prostaglandin D receptor activity] GO:0004958 [prostaglandin F receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0042923 [neuropeptide binding] GO:0043005 [neuron projection] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:2000255 [negative regulation of male germ cell proliferation] Show all	395 aa 43.3 kDa	No	7