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PTGDR2

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GENERAL INFORMATION

Gene name

 PTGDR2

Gene description

 Prostaglandin D2 receptor 2

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (NB-4, HEL, HMC-1, K-562, Hep G2, MOLT-4)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (NB-4, HEL, HMC-1, K-562, Hep G2, MOLT-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PTGDR2 (HGNC Symbol)

Synonyms

 CD294, CRTH2, DP2, GPR44

Description

 Prostaglandin D2 receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]

Chromosome

 11

Cytoband

 q12.2

Chromosome location (bp)

 60850940 - 60855971

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183134 (version 83.38)

Entrez gene

 11251

UniProt

 Q9Y5Y4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5Y4

Antibodypedia

 PTGDR2 antibodies

PROTEIN BROWSER
PTGDR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGDR2-001
ENSP00000332812
ENST00000332539
Q9Y5Y4 [Direct mapping]
Prostaglandin D2 receptor 2
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001785 [prostaglandin J receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004956 [prostaglandin D receptor activity]
GO:0004958 [prostaglandin F receptor activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:2000255 [negative regulation of male germ cell proliferation]
Show all
 395 aa
43.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.